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Effects of One-dose Varicella Vaccination on Disease Severity in Children during Outbreaks in Seoul, Korea
Journal of Korean Medical Science ; : e83-2019.
Article Dans Anglais | WPRIM | ID: wpr-764924
ABSTRACT

BACKGROUND:

In Korea, the incidence of varicella has increased despite the introduction of a universal one-dose vaccination for children aged 12–15 months in 2005. A previous study demonstrated that the vaccine effectiveness was insufficient to prevent against varicella. We assessed the effect of the varicella vaccination on disease severity.

METHODS:

Epidemiologic investigation of varicella cases in Seoul metropolitan area from 2015 to 2017 were used. Varicella-related symptoms such as rash were determined by the clinical practitioners. Disease severity of patients was assessed by the number of skin lesions and divided into mild (≤ 50) and moderate (51–249) to severe (≥ 250). Unconditional logistic regression analysis was performed and age was controlled.

RESULTS:

Among a total of 1,008 varicella cases reported, 869 cases were breakthrough cases and 139 were unvaccinated cases. The risk for occurrence of moderate-to-severe disease in the breakthrough group was 0.57 times less than that of the unvaccinated group.

CONCLUSION:

These data suggest that national varicella vaccination may have a significant effect on attenuation of disease severity in children.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Peau / Modèles logistiques / Varicelle / Incidence / Épidémies de maladies / Vaccination / Exanthème / Séoul / Corée Type d'étude: Etude d'incidence / Étude pronostique / Facteurs de risque Limites du sujet: Enfant / Humains Pays comme sujet: Asie langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2019 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Peau / Modèles logistiques / Varicelle / Incidence / Épidémies de maladies / Vaccination / Exanthème / Séoul / Corée Type d'étude: Etude d'incidence / Étude pronostique / Facteurs de risque Limites du sujet: Enfant / Humains Pays comme sujet: Asie langue: Anglais Texte intégral: Journal of Korean Medical Science Année: 2019 Type: Article