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Therapeutic Approaches to Atrophic Vaginitis in Postmenopausal Women: A Systematic Review with a Network Meta-analysis of Randomized Controlled Trials
Journal of Menopausal Medicine ; : 1-10, 2018.
Article Dans Anglais | WPRIM | ID: wpr-765732
ABSTRACT

OBJECTIVES:

Atrophic vaginitis (AV), which is common in postmenopausal women, is characterized by vaginal dryness, dyspareunia, and discomfort. There are a variety of therapeutic agents for the treatment of AV, besides hormone replacement therapy. We performed this systematic review to compare the effectiveness of various therapies for symptom improvement in AV patients.

METHODS:

We searched the Cochrane Library, EMBASE, MEDLINE, and other literature (Google Scholar, Web of Science, and hand search) for studies published between January 2010 and March 2015. AV was evaluated by the following

outcomes:

vaginal pH, dyspareunia, vaginal dryness, or cytological change (endometrial thickness, percentages of superficial cells and parabasal cells). They measured treatment efficacy with various outcomes pertaining to AV symptoms.

RESULTS:

Meta-analysis suggested that ospemifene was effective against dyspareunia, vaginal dryness, endometrial thickness, and percentage changes in superficial and parabasal cells. Vaginal pH was most affected by soy isoflavone vaginal gel. Ospemifene was effective for AV symptoms.

CONCLUSIONS:

This systematic review compared the effects of several therapeutic agents on symptoms of AV through a network meta-analysis. This study provides objective evidence for clinical treatment and efficacy management in AV.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Vagin / Crèmes, mousses et gels vaginaux / Résultat thérapeutique / Post-ménopause / Hormonothérapie substitutive / Dyspareunie / Vaginite atrophique / Main / Concentration en ions d'hydrogène Type d'étude: Essai clinique contrôlé / Revues systématiques évaluées Limites du sujet: Femelle / Humains langue: Anglais Texte intégral: Journal of Menopausal Medicine Année: 2018 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Vagin / Crèmes, mousses et gels vaginaux / Résultat thérapeutique / Post-ménopause / Hormonothérapie substitutive / Dyspareunie / Vaginite atrophique / Main / Concentration en ions d'hydrogène Type d'étude: Essai clinique contrôlé / Revues systématiques évaluées Limites du sujet: Femelle / Humains langue: Anglais Texte intégral: Journal of Menopausal Medicine Année: 2018 Type: Article