Assessment of Bone Mineral Density of Patients with Spinocerebellar Ataxia Type 3
Journal of Movement Disorders
;
: 43-46, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-765837
ABSTRACT
OBJECTIVE:
Machado-Joseph disease (MJD) is a spinocerebellar ataxia, and osteoporosis is a multifactor disease that may affect patients with neurologic conditions. The frequency of osteoporosis among MJD patients, however, has not been studied. The purpose of this study is to evaluate bone mineral density (BMD) and identify correlations between clinical factors and frequency of vertebral fractures in patients with MJD.METHODS:
Clinical data, lumbar X-rays and BMD data were obtained in 30 patients with MJD.RESULTS:
Ten patients (33.3%) showed low BMD in at least one of the sites studied based on Z-scores. The Z-score correlated directly with body mass index, and the femoral neck Z-score was inversely correlated with cytosine-adenine-guanine (CAG) expansion. There was no correlation between BMD and other clinical factors. Forty-three percent of the patients reported previous pathologic fractures. Five patients (16.7%) had at least one fracture detected by lumbar X-ray.CONCLUSION:
Low BMD and fractures are frequent among MJD patients, and careful management of BMD may be beneficial for these patients.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ostéoporose
/
Indice de masse corporelle
/
Densité osseuse
/
Maladie de Machado-Joseph
/
Ataxies spinocérébelleuses
/
Col du fémur
/
Fractures spontanées
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Journal of Movement Disorders
Année:
2019
Type:
Article
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