Interrelationship of Uric Acid, Gout, and Metabolic Syndrome: Focus on Hypertension, Cardiovascular Disease, and Insulin Resistance
Journal of Rheumatic Diseases
;
: 19-27, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-766164
ABSTRACT
The mean serum uric acid level and the prevalence of hyperuricemia have increased over the past few decades. Hyperuricemia is considered to be responsible for the increased risk of hypertension, insulin resistance, and cardiovascular disease. Metabolic syndrome also contributes to the development of type II diabetes mellitus and cardiovascular disease. Despite the close relationships between uric acid and the components of metabolic syndrome, the causal effect of uric acid on these clinical issues is unclear. Recent studies have revealed the possible development of metabolic syndrome mediated by fructose-induced hyperuricemia. This review summarizes the available clinical and experimental data supporting the causal effect of uric acid on the components of metabolic syndrome, including hypertension, cardiovascular disease, and insulin resistance.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Acide urique
/
Insulinorésistance
/
Maladies cardiovasculaires
/
Prévalence
/
Hyperuricémie
/
Diabète
/
Goutte
/
Hypertension artérielle
/
Insuline
Type d'étude:
Étude de prévalence
langue:
Anglais
Texte intégral:
Journal of Rheumatic Diseases
Année:
2018
Type:
Article
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