Experimental Study of Disodium Etidronate for the Growth of MC3T3-E1 Osteoblastic Cell Line / 대한정형외과학회잡지
The Journal of the Korean Orthopaedic Association
;
: 553-561, 1990.
Article
Dans Coréen
| WPRIM
| ID: wpr-769185
ABSTRACT
In the general, Disodium estdronate (EHDP) had effects of inhibition in bone resorption, dissolution of hydroxyapatite crystal and decreasing the turn over rate in Paget's disease. Clinically it is used as the drug of treatment for the osteoporosis, heterotropic ossificatiom and Paget's disease inspite of some, controvesies, but there is few article about the effect of EHDP on osteoblast. Authors tries to observe the effect of EHDP on osteoblast using the MC3T3-El osteoblast cell line which has very similar chrateristics with human osteoblast and evaluate the effect by the criteria of changes of morphology, number of osteoblast, and alkaline phosphatase activity. The results are obtained as following l. EHDP has direct inhibitory effect on the proliferation of osteoblast. 2. EHDP increase the alkaline phosphatase activity in vitro.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ostéoblastes
/
Ostéoporose
/
Résorption osseuse
/
Techniques in vitro
/
Lignée cellulaire
/
Acide étidronique
/
Durapatite
/
Phosphatase alcaline
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
The Journal of the Korean Orthopaedic Association
Année:
1990
Type:
Article
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