Early Detection and Prognosis Prediction of Severe sepsis and Septic shock in Emergency Triage Room
Journal of the Korean Society of Emergency Medicine
;
: 657-664, 2008.
Article
Dans Coréen
| WPRIM
| ID: wpr-77147
ABSTRACT
PURPOSE:
Biochemical markers can help predict neurological outcome in post-resuscitation patients. This prospective study evaluated the prognostic value of serum S100B protein and neuron-specific enolase (NSE) time courses in predicting unfavorable neurological outcomes.METHODS:
We serially measured serum S100B protein and NSE levels 12 times during the 96 h after the return of spontaneous circulation (ROSC) in 40 patients. Neurological outcome was assessed at 6 months after cardiac arrest. Patients were divided into good (CPC 1 to 2) and poor (CPC 3 to 5) neurological outcome groups and assessed for cerebral performance category scores. We compared the two groups at each serum value and calculated cut-off values.RESULTS:
Serum S100B protein levels over the study period, except at 4 hours, and NSE levels from 14 hours after ROSC were significantly higher in the poor neurological outcome group (n=32) than the good neurological outcome group (n=8). The most predictive serum S100B protein and NSE times were at 14 hours (cut off value=0.16 microgram/L, sensitivity 81.8%, specificity 100%, AUC=0.938) and 54 hours (cut off value=19.21 microgram/L, sensitivity 86.4%, specificity 100%, AUC=0.932).CONCLUSION:
Serum S100B protein and NSE levels are early and useful markers for assessing neurological outcome after successful resuscitation from cardiac arrest.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Enolase
/
Pronostic
/
Réanimation
/
Choc septique
/
Marqueurs biologiques
/
Protéines S100
/
Études prospectives
/
Triage
/
Sensibilité et spécificité
/
Sepsie
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
/
Étude de dépistage
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Journal of the Korean Society of Emergency Medicine
Année:
2008
Type:
Article
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