Advances in the application of claudins to tumor therapy / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 931-941, 2019.
Article
Dans Chinois
| WPRIM
| ID: wpr-771833
ABSTRACT
Claudin proteins are the most crucial components of tight junctions, and play an essential role in maintaining cell polarity, regulating cell permeability and the intercellular ion. In recent years, many studies have shown that abnormality of claudins expression is implicated in the tumor progression. The expression correlates with tumor prognosis and can serve as a biomarker of prognosis and potential therapeutic targets. This review summarizes the current knowledge regarding claudin dysregulation in cancer and highlights the progress in claudin-based treatments.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Jonctions serrées
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Entérotoxines
/
Claudines
/
Tumeurs
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Chinese Journal of Biotechnology
Année:
2019
Type:
Article
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