Clinical Evaluation of A New Pathological Classification for
Non-small Cell Lung Cancer Based on Histogenesis of Bronchial Tree / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 530-535, 2018.
Article
Dans Chinois
| WPRIM
| ID: wpr-772406
ABSTRACT
BACKGROUND@#Due in part to remarkable advances over the past decade in our understanding of lung cancer, there is a pressing need for a revised classification. The aim of this study was to explore and verify the clinical significance of a new molecular classification of non-small cell lung cancer (NSCLC) on the basis of anatomic site of bronchial tree.@*METHODS@#Double-immunohistochemistry were performed in 105 tumor samples paring with normal lung tissue from non-small cell lung cancer patients by using monoclonal antibody of P63/NapsinA and TTF-1/CK7. By comprehensively analyzing the express profiles of tumors and normal lung tissues, histological characteristics we proposed a brand new pathological classification based on histogenesis for NSCLC and divided them as bronchiole epithelial cell carcinoma, bronchiole-alveolar cell carcinoma, alveolar cell carcinoma and secretory adenocarcinoma. And to analyze the relationship between this classification and epidermal growth factor receptor (EGFR) mutation and ognosis.@*RESULTS@#Further investigation revealed that our new classification showed strong relevancy with EGFR mutations and effective indicators for prognosis.@*CONCLUSIONS@#The classification system for NSCLC proposed by our research group is convenient for pathological diagnosis and valuable in clinical application.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Bronches
/
Classification
/
Carcinome pulmonaire non à petites cellules
/
Tumeurs du poumon
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Lung Cancer
Année:
2018
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS