Rat model with oral submucous fibrosis induced by arecoline and mechanical stimulation / 华西口腔医学杂志
West China Journal of Stomatology
;
(6): 260-264, 2019.
Article
Dans Chinois
| WPRIM
| ID: wpr-772665
ABSTRACT
OBJECTIVE@#The aim of this study was to induce oral submucous fibrosis (OSF) in Sprague-Dawley(SD) rat models by arecoline and mechanical stimulation.@*METHODS@#Two factors factorial design was used to divide 48 rats into 8 groups (n=6). Different concentrations of arecoline (0, 0.5, 2, and 8 mg·mL⁻¹) and mechanical stimulation (with or without brush) were treated. After 16 weeks of treatment, the mouth opening was measured, the pathological changes of the buccal mucosa were observed, and the expressions of type Ⅲ collagen, transforming growth factor β1 (TGF-β1), and interferon-γ (IFN-γ) were detected.@*RESULTS@#In rats with moderate and high concentrations of arecoline, typical OSF pathological features were observed in the buccal mucosa, the mouth openings were significantly reduced, and the expression levels of type Ⅲ colla-gen and TGF-β1 were significantly increased (P0.05).@*CONCLUSIONS@#Moderate and high concentrations of arecoline can induce OSF in SD rats, but mechanical stimulation cannot induce OSF.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Fibrose buccale sous-muqueuse
/
Pharmacologie
/
Arécoline
/
Rat Sprague-Dawley
/
Fibroblastes
/
Muqueuse de la bouche
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
West China Journal of Stomatology
Année:
2019
Type:
Article
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