Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas / 医学前沿
Frontiers of Medicine
; (4): 497-508, 2018.
Article
de En
| WPRIM
| ID: wpr-772710
Bibliothèque responsable:
WPRO
ABSTRACT
Viral infections cause at least 10%-15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virus-related carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Antiviraux
/
Thérapeutique
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Infections à virus oncogènes
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Virologie
/
Carcinomes
/
Thérapie génétique
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Prédisposition génétique à une maladie
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Utilisations thérapeutiques
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Systèmes CRISPR-Cas
/
Édition de gène
Limites du sujet:
Humans
langue:
En
Texte intégral:
Frontiers of Medicine
Année:
2018
Type:
Article