NKT cells in liver diseases / 医学前沿
Frontiers of Medicine
;
(4): 249-261, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-772711
ABSTRACT
Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases. In this study, we summarize recent findings on biology of natural killer T cells and their roles in hepatitis B virus and hepatitis C virus infection, autoimmune liver diseases, alcoholic liver disease, nonalcoholic fatty liver disease, and hepatocellular carcinoma. Controversial results from previous studies are discussed, and indicate the dynamic alteration in the role of natural killer T cells during the progression of liver diseases, which might be caused by changes in natural killer T subsets, factors skewing cytokine responses, and intercellular crosstalk between natural killer T cells and CD1d-expressing cells or bystander cells.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Maladies auto-immunes
/
Allergie et immunologie
/
Cellules T tueuses naturelles
/
Foie
/
Maladies du foie
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Frontiers of Medicine
Année:
2018
Type:
Article
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