γδ T cells in liver diseases / 医学前沿
Frontiers of Medicine
; (4): 262-268, 2018.
Article
de En
| WPRIM
| ID: wpr-772720
Bibliothèque responsable:
WPRO
ABSTRACT
γδ T cells display unique developmental, distributional, and functional patterns and can rapidly respond to various insults and contribute to diverse diseases. Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues. γδ T cells are enriched in the liver and exhibit liver-specific features. Accumulating evidence reveals that γδ T cells play important roles in liver infection, non-alcoholic fatty liver disease, autoimmune hepatitis, liver fibrosis and cirrhosis, and liver cancer and regeneration. In this study, we review the properties of hepatic γδ T cells and summarize the roles of γδ T cells in liver diseases. We believe that determining the properties and functions of γδ T cells in liver diseases enhances our understanding of the pathogenesis of liver diseases and is useful for the design of novel γδ T cell-based therapeutic regimens for liver diseases.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Cytokines
/
Lymphocytes T régulateurs
/
Allergie et immunologie
/
Maladies du foie
/
Régénération hépatique
Limites du sujet:
Animals
/
Humans
langue:
En
Texte intégral:
Frontiers of Medicine
Année:
2018
Type:
Article