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Systematic review of external applications combined with three-step analgesic therapy in treating primary liver cancer pain / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1938-1945, 2019.
Article Dans Chinois | WPRIM | ID: wpr-773145
ABSTRACT
To systemically evaluate the clinical efficacy and safety of traditional Chinese medicine( TCM) external application combined with three-step analgesic therapy in treating primary liver cancer pain. CNKI,Wanfang,CBM,VIP,Medline and Cochrane Library and manual retrieval were used to search for the clinical randomized controlled trials on TCM external applications combined with three-step analgesic therapy in treating primary liver cancer pain from database establishment to January,2018. The bias risk of RCTs was assessed by using the Cochrane system evaluator's Manual,and the extracted data were analyzed by using Review Manager 5. 3. Finally sixteen Chinese articles were enrolled,including one high quality article and 1 164 patients. Meta-analysis showed that TCM external applications combined with three-step analgesic therapy could alleviate the cancer pain( OR = 3. 44,95% CI[2. 49,4. 75],P <0. 000 01); prolong pain relief time( SMD = 3. 42,95%CI[1. 83,6. 40],Z = 3. 85,P = 0. 000 1); and improve the cartesian score of the patients( OR = 3. 42,95%CI[1. 83,6. 40],P = 0. 000 01). Descriptive analysis showed that the intervention may effectively shorten the onset time of pain relief,reduce VAS and NRS scores,reduce the dose of morphine,and reduce the number of bursts of pain. At present,the evidences have shown that the combination of TCM external applications combined with three-step analgesic therapy in treating primary liver cancer pain has superior clinical efficacy as compared with the three-step analgesic therapy alone. However,the clinical trials of existing small-sized randomized controlled trials have low quality of methodology and require a large sample of high quality clinical trials for further validation.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Douleur / Essais contrôlés randomisés comme sujet / Utilisations thérapeutiques / Gestion de la douleur / Analgésiques / Tumeurs du foie / Médecine traditionnelle chinoise Type d'étude: Essai clinique contrôlé / Etude diagnostique / Guide de pratique / Revues systématiques évaluées Limites du sujet: Humains langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2019 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Douleur / Essais contrôlés randomisés comme sujet / Utilisations thérapeutiques / Gestion de la douleur / Analgésiques / Tumeurs du foie / Médecine traditionnelle chinoise Type d'étude: Essai clinique contrôlé / Etude diagnostique / Guide de pratique / Revues systématiques évaluées Limites du sujet: Humains langue: Chinois Texte intégral: China Journal of Chinese Materia Medica Année: 2019 Type: Article