Study on liver protection and hepatotoxicity of saikosaponin a based on zebrafish model / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2662-2666, 2019.
Article
Dans Chinois
| WPRIM
| ID: wpr-773276
ABSTRACT
Bupleuri Radix has both liver protection and hepatotoxicity. Saponins are the main pharmacodynamic and toxic components of Bupleuri Radix. Based on zebrafish physical model and the model of alcoholic fatty liver( AFL) pathology,the liver toxic and protective effect of saikosaponin a( SSa) were assessed. The results indicated that 1. 77 μmol·L-1 SSa showed protective effect to AFL zebrafish. 5. 30 μmol·L-1 SSa was hepatotoxic to healthy zebrafish,but it showed protective effect to AFL zebrafish. 5. 62 μmol·L-1 SSa was hepatotoxic to healthy and AFL zebrafish. This study is benefit for clinical safety of saikosaponin a.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Acide oléanolique
/
Pharmacologie
/
Saponines
/
Danio zébré
/
Traitement médicamenteux
/
Toxicité
/
Stéatose hépatique alcoolique
/
Lésions hépatiques dues aux substances
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2019
Type:
Article
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