Enhancement of gut permeation of amoxicillin with Nigella sativa seed extract and its phytochemical screening / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 125-130, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-773634
ABSTRACT
The seeds of Nigella sativa Linn. (Ranunculaceae), commonly known as Black cumin, are predominantly used as carminative, antispasmodic, and stimulant. The main objective of the present study was to evaluate the effect of N. sativa seed extract on the permeation of co-infused amoxicillin across the gut wall. The methanolic extract of N. sativa improved intestinal permeability of amoxicillin in in-vitro experiments in a dose-dependent manner. Two new glycosides, decanyl nigelloic acid diglucoside [n-decanyl-3-aldehydic-4-methoxy-5-hydroxy benzoate-5-β-D-glucofuranosyl (2→1)-β-D-glucopyranosyl-(2→1)-β-D-glucopyranoside]] and nigelabdienoyl triglucoside [homo-labd-5, 9(11)-dien-16-onyl-β-D-glucopyranosyl (2→1)-β-D-glucopyranosyl (2→1)-β-D-glucopyranoside], along with seven known fatty acid glycerides/esters, were isolated from the gut permeation enhancing extract. The structures of these new glycosides were elucidated by detailed spectroscopic analyses.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Graines
/
Pharmacocinétique
/
Extraits de plantes
/
Structure moléculaire
/
Chimie
/
Nigella sativa
/
Rat Wistar
/
Composés phytochimiques
/
Amoxicilline
/
Intestin grêle
Type d'étude:
Etude diagnostique
/
Étude de dépistage
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2018
Type:
Article
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