Polyomavirus Induced Interstital Nephritis in Renal Allograft Recipient / 대한이식학회지
The Journal of the Korean Society for Transplantation
;
: 313-318, 1998.
Article
Dans Coréen
| WPRIM
| ID: wpr-77450
ABSTRACT
We report our experience of renal polyomavirus infection after renal allograft leading to graft dysfunction. A fourty seven-years-old male patient, has been on Tacrolimus based dual immunosuppression, showed graft dysfunction with rising serum creatinine at post-transplant day 140. His graft function had been good without any acute rejection episode. A tentative diagnosis of acute rejection was rendered and core needle biopsy was performed. Viral infection was initially suggested by the occurrence of markedly enlarged tubular epithelial cells containing large nuclei with smudgy chromatin pattern. Confirmatory diagnosis of human polyomavirus induced interstitial nephritis was obtained by electron microscopy, which showed viral particles in the nuclei of tubular epithelial cells. After Tacrolimus was converted to cyclosporine, renal function was stabilized. A review of the literature indicates that asymptomatic infection, ureteric stricture, and hemorrhagic cystitis are other possible manifestations of polyomavirus in the human urogenital tract. According to some prior reports, polyomavirus induced interstitial nephritis might be a cause of graft loss. But our patient has retained a stable graft function with a chnange of immunosuppression.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Uretère
/
Virion
/
Chromatine
/
Microscopie électronique
/
Immunosuppression thérapeutique
/
Tacrolimus
/
Ciclosporine
/
Polyomavirus
/
Sténose pathologique
/
Transplants
Type d'étude:
Etude diagnostique
Limites du sujet:
Humains
/
Mâle
langue:
Coréen
Texte intégral:
The Journal of the Korean Society for Transplantation
Année:
1998
Type:
Article
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