MicroRNA-132 in the Adult Dentate Gyrus is Involved in Opioid Addiction Via Modifying the Differentiation of Neural Stem Cells / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 486-496, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-775423
ABSTRACT
MicroRNA-132 (miR-132), a small RNA that regulates gene expression, is known to promote neurogenesis in the embryonic nervous system and adult brain. Although exposure to psychoactive substances can increase miR-132 expression in cultured neural stem cells (NSCs) and the adult brain of rodents, little is known about its role in opioid addiction. So, we set out to determine the effect of miR-132 on differentiation of the NSCs and whether this effect is involved in opioid addiction using the rat morphine self-administration (MSA) model. We found that miR-132 overexpression enhanced the differentiation of NSCs in vivo and in vitro. Similarly, specific overexpression of miR-132 in NSCs of the adult hippocampal dentate gyrus (DG) during the acquisition stage of MSA potentiated morphine-seeking behavior. These findings indicate that miR-132 is involved in opioid addiction, probably by promoting the differentiation of NSCs in the adult DG.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Différenciation cellulaire
/
Régulation de l'expression des gènes
/
Rat Sprague-Dawley
/
Gyrus denté
/
MicroARN
/
Lignée cellulaire tumorale
/
Cellules souches neurales
/
Métabolisme
/
Troubles liés aux opiacés
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Neuroscience Bulletin
Année:
2019
Type:
Article
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