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Taurine Transporter dEAAT2 is Required for Auditory Transduction in Drosophila / 神经科学通报·英文版
Neuroscience Bulletin ; (6): 939-950, 2018.
Article Dans Anglais | WPRIM | ID: wpr-775496
ABSTRACT
Drosophila dEAAT2, a member of the excitatory amino-acid transporter (EAAT) family, has been described as mediating the high-affinity transport of taurine, which is a free amino-acid abundant in both insects and mammals. However, the role of taurine and its transporter in hearing is not clear. Here, we report that dEAAT2 is required for the larval startle response to sound stimuli. dEAAT2 was found to be enriched in the distal region of chordotonal neurons where sound transduction occurs. The Ca imaging and electrophysiological results showed that disrupted dEAAT2 expression significantly reduced the response of chordotonal neurons to sound. More importantly, expressing dEAAT2 in the chordotonal neurons rescued these mutant phenotypes. Taken together, these findings indicate a critical role for Drosophila dEAAT2 in sound transduction by chordotonal neurons.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Physiologie / Voies auditives / Stimulation acoustique / Potentiels d'action / Animal génétiquement modifié / Calcium / Biologie cellulaire / Transporteur-2 d'acides aminés excitateurs / Protéines de Drosophila / Drosophila Limites du sujet: Animaux langue: Anglais Texte intégral: Neuroscience Bulletin Année: 2018 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Physiologie / Voies auditives / Stimulation acoustique / Potentiels d'action / Animal génétiquement modifié / Calcium / Biologie cellulaire / Transporteur-2 d'acides aminés excitateurs / Protéines de Drosophila / Drosophila Limites du sujet: Animaux langue: Anglais Texte intégral: Neuroscience Bulletin Année: 2018 Type: Article