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Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness / 神经科学通报·英文版
Neuroscience Bulletin ; (6): 647-658, 2018.
Article Dans Anglais | WPRIM | ID: wpr-775510
ABSTRACT
A number of studies have indicated that disorders of consciousness result from multifocal injuries as well as from the impaired functional and anatomical connectivity between various anterior forebrain regions. However, the specific causal mechanism linking these regions remains unclear. In this study, we used spectral dynamic causal modeling to assess how the effective connections (ECs) between various regions differ between individuals. Next, we used connectome-based predictive modeling to evaluate the performance of the ECs in predicting the clinical scores of DOC patients. We found increased ECs from the striatum to the globus pallidus as well as from the globus pallidus to the posterior cingulate cortex, and decreased ECs from the globus pallidus to the thalamus and from the medial prefrontal cortex to the striatum in DOC patients as compared to healthy controls. Prediction of the patients' outcome was effective using the negative ECs as features. In summary, the present study highlights a key role of the thalamo-basal ganglia-cortical loop in DOCs and supports the anterior forebrain mesocircuit hypothesis. Furthermore, EC could be potentially used to assess the consciousness level.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Imagerie diagnostique / Imagerie par résonance magnétique / Théorème de Bayes / Prosencéphale / Troubles de la conscience / Connectome / Apprentissage machine / Voies nerveuses Type d'étude: Etude diagnostique / Étude pronostique Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Anglais Texte intégral: Neuroscience Bulletin Année: 2018 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / Imagerie diagnostique / Imagerie par résonance magnétique / Théorème de Bayes / Prosencéphale / Troubles de la conscience / Connectome / Apprentissage machine / Voies nerveuses Type d'étude: Etude diagnostique / Étude pronostique Limites du sujet: Adulte / Femelle / Humains / Mâle langue: Anglais Texte intégral: Neuroscience Bulletin Année: 2018 Type: Article