Advances in research on gene and cell therapy for type IV collagen related hereditary kidney diseases / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 179-182, 2019.
Article
de Zh
| WPRIM
| ID: wpr-775783
Bibliothèque responsable:
WPRO
ABSTRACT
Type IV collagen is a component of the extracellular matrix in the basement membrane. Abnormal secretion or assembly of type IV collagen may lead to kidney lesions resulting in numerous nephropathy symptoms, e.g., Alport syndrome, thin basement membrane nephropathy, and focal segmental glomerulosclerosis. Treatment for type IV collagen-related nephropathy includes drugs, kidney transplantation, gene and cell therapy. However, drugs are not always effective, and kidney transplantation is hindered by the shortage of donors. Moreover, basement membrane nephritis often occurs after kidney transplantation. Therefore, gene and cell therapy probably is the most promising treatment for type IV collagen related nephropathies.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Glomérulonéphrite segmentaire et focale
/
Collagène de type IV
/
Thérapie cellulaire et tissulaire
/
Hématurie
/
Néphropathie familiale avec surdité
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2019
Type:
Article