Two cases of rare diseases with abnormalities of X chromosome / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 151-153, 2019.
Article
de Zh
| WPRIM
| ID: wpr-775791
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE@#To explore the clinical features and genetic diagnosis of two cases with rare diseases and X chromosome abnormalities.@*METHODS@#Multiple ligation-dependent probe amplification (MLPA) and karyotype analysis were carried out on an 8-year-old girl who was diagnosed with Duchenne muscular dystrophy. Karyotype analysis and PCR assay for SRY and AZF genes were carried out for a-2-month-old male infant with short penis.@*RESULTS@#The girl, who featured short stature and cubitus valgus, was diagnosed as Turner syndrome with a karyotype of 46,X,i(Xq). The male infant was detected with a karyotype of 45,X, with presence of SRY gene but absence of AZF gene.@*CONCLUSION@#Both cases may be associated with abnormalities of X chromosome. Genetic testing can facilitate early diagnosis and clinical intervention for such patients.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Syndrome de Turner
/
Myopathie de Duchenne
/
Chromosomes X humains
/
Maladies rares
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Génétique
/
Caryotypage
Type d'étude:
Screening_studies
Limites du sujet:
Humans
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Infant
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Male
langue:
Zh
Texte intégral:
Chinese Journal of Medical Genetics
Année:
2019
Type:
Article