Withaminimas A-F, six withanolides with potential anti-inflammatory activity from Physalis minima / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 469-474, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-776864
ABSTRACT
Withaminimas A-F (1-6), six new withaphysalin-type withanolides were isolated from the aerial parts of Physalis minima L.. The structures of these compounds were elucidated through a variety of spectroscopic techniques including HR-MS, NMR, and ECD. Compound 1 belongs to rare 18-norwithanolides, and 2-3 were 13/14-secowithanolides. According to the traditional usage of P. minima, inhibitory effects on nitric oxide (NO) production in lipopolysaccaride-activated RAW264.7 macrophages were evaluated, and compounds 1-4 exhibited significant inhibitory effects with IC values among 3.91-18.46 μmol·L.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Relation structure-activité
/
Médicaments issus de plantes chinoises
/
Structure moléculaire
/
Chimie
/
Lipopolysaccharides
/
Physalis
/
Allergie et immunologie
/
Withanolides
/
Macrophages
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2019
Type:
Article
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