AATYK is a Novel Regulator of Oligodendrocyte Differentiation and Myelination / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 527-533, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-777035
ABSTRACT
Oligodendrocytes (OLs) are myelinating glial cells that form myelin sheaths around axons to ensure rapid and focal conduction of action potentials. Here, we found that an axonal outgrowth regulatory molecule, AATYK (apoptosis-associated tyrosine kinase), was up-regulated with OL differentiation and remyelination. We therefore studied its role in OL differentiation. The results showed that AATYK knockdown inhibited OL differentiation and the expression of myelin genes in vitro. Moreover, AATYK-deficiency maintained the proliferation status of OLs but did not affect their survival. Thus, AATYK is essential for the differentiation of OLs.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Physiologie
/
Protein-tyrosine kinases
/
Différenciation cellulaire
/
Cellules cultivées
/
Oligodendroglie
/
Maladies démyélinisantes
/
Rat Sprague-Dawley
/
Régulation de l'expression des gènes au cours du développement
/
Protéine protéolipidique myéline
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Neuroscience Bulletin
Année:
2018
Type:
Article
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