Effects of Ketamine on Basal Gamma Band Oscillation and Sensory Gating in Prefrontal Cortex of Awake Rats / 神经科学通报·英文版
Neuroscience Bulletin
; (6): 457-464, 2018.
Article
de En
| WPRIM
| ID: wpr-777043
Bibliothèque responsable:
WPRO
ABSTRACT
Gamma band oscillation (GBO) and sensory gating (SG) are associated with many cognitive functions. Ketamine induces deficits of GBO and SG in the prefrontal cortex (PFC). However, the time-courses of the effects of different doses of ketamine on GBO power and SG are poorly understood. Studies have indicated that GBO power and SG have a common substrate for their generation and abnormalities. In this study, we found that (1) ketamine administration increased GBO power in the PFC in rats differently in the low- and high-dose groups; (2) auditory SG was significantly lower than baseline in the 30 mg/kg and 60 mg/kg groups, but not in the 15 mg/kg and 120 mg/kg groups; and (3) changes in SG and basal GBO power were significantly correlated in awake rats. These results indicate a relationship between mechanisms underlying auditory SG and GBO power.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
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Phases du sommeil
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Facteurs temps
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Vigilance
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Stimulation acoustique
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Statistiques comme sujet
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Analyse de variance
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Rat Sprague-Dawley
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Cortex préfrontal
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Antagonistes des acides aminés excitateurs
Limites du sujet:
Animals
langue:
En
Texte intégral:
Neuroscience Bulletin
Année:
2018
Type:
Article