Nuclear receptors and renal water transport regulation / 生理学报
Acta Physiologica Sinica
;
(6): 630-638, 2018.
Article
Dans Chinois
| WPRIM
| ID: wpr-777221
ABSTRACT
The function of kidney is maintaining water balance of our body through regulation of urine concentration and dilution. The aquaporins are molecular basis of renal urine production and water transport, and their expression and membrane translocation are regulated delicately. Nuclear receptors are a superfamily of ligand-activated transcription factors consisting of 48 members in human. They widely participate in a variety of physiological and pathophysiological regulation including growth and development, glucose and lipid metabolism, inflammation, immunology by regulating target gene transcription and expression. Increasing evidence demonstrates that these receptors are involved in the regulation of aquaporins expression and membrane translocation in kidney, thereby playing a major role in water homeostasis. Here we review the role of nuclear receptors in regulating renal water transport.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Transport biologique
/
Eau
/
Récepteurs cytoplasmiques et nucléaires
/
Aquaporines
/
Homéostasie
/
Rein
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Acta Physiologica Sinica
Année:
2018
Type:
Article
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