Role and mechanism of action of adipocytokines in the progression of liver fibrosis / 临床肝胆病杂志

ABSTRACT

Liver fibrosis is an essential stage in the development and progression of liver cirrhosis, and uncontrolled liver fibrosis may eventually lead to liver cirrhosis and/or hepatocellular carcinoma. Liver fibrosis is a dynamic process regulated by many factors. An increasing number of evidence has shown that adipokines transmit dynamic functions in the liver and are involved in the regulation of liver fibrosis. This article reviews the research on major adipocytokines (adiponectin and leptin) involved in liver fibrosis and the recent advances in the mechanism of action of these adipocytokines in liver fibrosis.