Design, synthesis and biological evaluation of oxadiazole derivatives as xanthine oxidase inhibitors / 药学学报
Acta Pharmaceutica Sinica
;
(12): 954-2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-779262
ABSTRACT
Xanthine oxidase (XO) is an important target for the treatment of hyperuricemia and gout. Based on the two known non-purine xanthine oxidase inhibitors, febuxostat and topiroxostat, 14 oxadiazole derivatives have been designed and synthesized. These compounds have been evaluated against XO and five of them exhibited significant inhibitory activities at the concentrations below 10 μmol·L-1.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2016
Type:
Article
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