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Design, synthesis and biological evaluation of amide derivatives as xanthine oxidase inhibitors / 药学学报
Acta Pharmaceutica Sinica ; (12): 952-958, 2017.
Article Dans Chinois | WPRIM | ID: wpr-779680
ABSTRACT
Xanthine oxidase (XO) is a key enzyme in the synthesis of uric acid. Therefore, XO inhibitors play an important role in the antihyperuricemic therapy. Based on the template structures of febuxostat and topiroxostat, 18 amide derivatives were designed and synthesized. Among them, six showed apparent inhibitory activity against XO under the concentration of 10 μmol·L-1. Molecular docking revealed the possible interaction mode of this compound class, which may provide a clue for further molecular design.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: Acta Pharmaceutica Sinica Année: 2017 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: Acta Pharmaceutica Sinica Année: 2017 Type: Article