The progress of multifunctional envelope-type nano device / 药学学报
Acta Pharmaceutica Sinica
;
(12): 47-53, 2018.
Article
Dans Chinois
| WPRIM
| ID: wpr-779843
ABSTRACT
The key of gene therapy is to deliver the functional gene to the target tissue in the body. The safe and efficient gene carrier is particularly important in the targeted delivery. Multifunctional envelope-type nano device (MEND), based on concept "Programmed packaging", is a new type of gene carrier system, with high encapsulation efficiency, favourable stability, high transfection efficiency, easy preparation, etc. MEND is designed to control intracellular trafficking as well as the tissue distribution of encapsulated compounds such as nucleic acids/proteins/peptides, permitting them to function at the appropriate location. In this paper, research progresses in MEND are reviewed in accordance with three types of payloadsthe small interfering RNA (siRNA), DNA and proteins/peptides in recent years.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2018
Type:
Article
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