Effect of CD56 Expression on Prognosis of AML Patients with AML/ETO Mutation / 中国实验血液学杂志

ABSTRACT

OBJECTIVE@#To investigate the expression and prognostic significance of CD56 in the patients suffered from acute myeloid leukemia with AML/ETO mutation.@*METHODS@#The clinical data of 60 newly diagnosed AML patients with AML/ETO from January 2012 to December 2016 were analyzed retrospectively. The clinical characteristics and outcome between CD56 and CD56 patients were compared.@*RESULTS@#There were significant differences in CR rate after one course chemotherapy, relapse rate within 1 year and gene mutations between the CD56 positive and negative patients (P＜0.05). The RFS and OS of CD56 positive patients were significantly lower than those of CD56 negative patients (P＜0.05).@*CONCLUSION@#The expression of CD56 may be an important factor of poor prognosis in AML patients with AML/ETO.