Occlusive Myocardial Infarction: Cardiac CT Perfusion in a Rat Model
Journal of the Korean Radiological Society
;
: 233-238, 2007.
Article
Dans Coréen
| WPRIM
| ID: wpr-78252
ABSTRACT
PURPOSE:
To test whether cardiac multidetector CT (MDCT) perfusion imaging can accurately delineate an irreversibly damaged myocardium in animals with an occlusive myocardial infarction. MATERIALS ANDMETHODS:
In 16 rats, the left anterior descending coronary arteries were ligated distal to its first diagonal artery after a thoracotomy. Thirty minutes after the procedure, 16-slice MDCT (Sensation 16, Siemens, Erlangen, Germany) was performed and delayed images were obtained up to 5 minutes after injecting the contrast agent (0.2 mL/100g, 0.5 mL/sec). Ten rats were re-examined one week later. After CT scanning, the rats were sacrificed and their hearts were extirpated for 2,3,5-triphenyltetrazolium chloride (TTC) histochemical staining. The stained slices were compared with the CT images. The CT number (HU) of the infarct and non-infarct areas were estimated from the contrast ratio (CR).RESULTS:
The CT attenuation in the infarct area was significantly lower than that in the normal myocardium. Quantitative analysis of the CT attenuation revealed a significant difference in the CR and CT attenuation of the infarct and reference areas (0.48+/-0.12 vs 0.64+/-0.13, p<0.05, 163+/-46 HU vs 216+/-56 HU, p<0.05). However, there were no significant differences in the CT numbers between the infarct and non-infarct areas on the one-week follow-up.CONCLUSION:
A perfusion defect on MDCT indicates the myocardial damage in an animal model with occlusive myocardial infarction.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Perfusion
/
Artères
/
Thoracotomie
/
Tomodensitométrie
/
Études de suivi
/
Vaisseaux coronaires
/
Modèles animaux
/
Imagerie de perfusion
/
Coeur
/
Infarctus du myocarde
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Journal of the Korean Radiological Society
Année:
2007
Type:
Article
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