Extraglandular Manifestations and Autoantibodies of Korean Patients with Primary Sjogren's Syndrome / 대한류마티스학회지

ABSTRACT

OBJECTIVE: To investigate the extraglandular manifestations and serological features of Korean patients with primary Sjogren's syndrome (pSS). METHODS: Clinical and laboratory data of 125 patients with pSS attending rheumatology clinic of Kangnam St. Mary's hospital, with a mean follow-up period of 64.8 months, were assessed retrospectively. RESULTS: Arthralgia was the most common extraglandular manifestation of pSS. Other extraglandular manifestations, such as myalgia, peripheral neuropathy, Raynaud's phenomenon, and hypothyroidism were frequently presented, but lymphoma was rare manifestation in Korean patients with pSS. Some extraglandular manifestations of pSS were associated with hypocomplementemia and antibodies against Ro, and La, and antinuclear antibody. CONCLUSION: The clinical manifestations and extraglandular manifestations of Korean patients with pSS patients were similar to other studies except low prevalence of lymphoma. Positivity of anti-Ro/SS-A, anti-La/SS-B antibodies and hypocomplementemia were closely associated with extraglandular manifestations in patients with pSS.