BONE REGENERATION WITH INJECTABLE MPEG-PCL DIBLOCK COPOLYMER AND BONE MARROW MESENCHYMAL STEM CELL
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
;
: 9-15, 2010.
Article
Dans Coréen
| WPRIM
| ID: wpr-784955
ABSTRACT
injectable scaffold, MPEG-PCL diblock copolymer was applied in bone tissue engineering. In vivo bone formation was evaluated by soft X-ray, histology based on the rat calvarial critical size defect model.MATERIALS AND METHODS:
New bone formation was evaluated with MPEG-PCL diblock copolymer in rat calvarial critical size bone defect. No graft was served as control. 4, 8 weeks after implantation, gross evidence of bone regeneration was evaluated by histology and soft X-ray analysis.RESULTS:
The improved and effective bone regeneration was achieved with the BMP-2 and osteoblasts loaded MPEG-PCL diblock copolymer.CONCLUSION:
It was confirmed that MPEG-PCL temperature sensitive hydrogels was useful as an injectable scaffold in bone regeneration.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ostéoblastes
/
Ostéogenèse
/
Polyesters
/
Polyéthylène glycols
/
Os et tissu osseux
/
Moelle osseuse
/
Régénération osseuse
/
Transplants
/
Hydrogels
/
Cellules souches mésenchymateuses
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Journal of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
Année:
2010
Type:
Article
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