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A Lower Baseline Urinary Glucose Excretion Predicts a Better Response to the Sodium Glucose Cotransporter 2 Inhibitor
Diabetes & Metabolism Journal ; : 898-905, 2019.
Article Dans Anglais | WPRIM | ID: wpr-785701
ABSTRACT
We aimed to identify the clinical variables associated with a better glucose-lowering response to the sodium glucose cotransporter 2 inhibitor ipragliflozin in people with type 2 diabetes mellitus (T2DM). We especially focused on urinary glucose excretion (UGE). This was a single-arm multicenter prospective study. A total of 92 people with T2DM aged 20 to 70 years with glycosylated hemoglobin (HbA1c) levels ≥7.0% and ≤9.5% were enrolled. Ipragliflozin (50 mg) was added to the background therapy for these people for 12 weeks. After 3 months treatment with ipragliflozin, the mean HbA1c levels were decreased from 7.6% to 6.9% and 62.0% of the people reached the HbA1c target of less than 7.0% (P<0.001). In addition, body weight, blood pressure, and lipid parameters were improved after ipragliflozin treatment (all P<0.001). The baseline HbA1c (r=0.66, P<0.001) and morning spot urine glucose to creatinine ratio (r=−0.30, P=0.001) were independently associated with the HbA1c reduction. Ipragliflozin treatment for 12 weeks improves glycemic control and other metabolic parameters. A higher HbA1c and lower UGE at baseline predicts a better glucose-lowering efficacy of ipragliflozin.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Sodium / Pression sanguine / Poids / Hémoglobine glyquée / Études prospectives / Créatinine / Diabète de type 2 / Transporteur-2 sodium-glucose / Glucose / Glycosurie Type d'étude: Essai clinique contrôlé / Étude observationnelle / Étude pronostique / Facteurs de risque langue: Anglais Texte intégral: Diabetes & Metabolism Journal Année: 2019 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Sodium / Pression sanguine / Poids / Hémoglobine glyquée / Études prospectives / Créatinine / Diabète de type 2 / Transporteur-2 sodium-glucose / Glucose / Glycosurie Type d'étude: Essai clinique contrôlé / Étude observationnelle / Étude pronostique / Facteurs de risque langue: Anglais Texte intégral: Diabetes & Metabolism Journal Année: 2019 Type: Article