B Cell Immunophenotyping and Transcriptional Profiles of Memory B Cells in Patients with Myasthenia Gravis
Experimental Neurobiology
;
: 720-726, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-785786
ABSTRACT
Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorders mediated by various autoantibodies. Although most patients with MG require chronic immunosuppressive treatment to control disease activity, appropriate surveillance biomarkers that monitor disease activity or potential toxicity of immunosuppressants are yet to be developed. Herein, we investigated quantitative distribution of peripheral blood B cell subsets and transcriptional profiles of memory B cells (CD19+ CD27+) in several subgroups of MG patients classified according to the Myasthenia Gravis Foundation of America (MGFA) Clinical Classification. This study suggests potential immunologic B-cell markers that may guide treatment decision in future clinical settings.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Autoanticorps
/
Amériques
/
Lymphocytes B
/
Marqueurs biologiques
/
Immunophénotypage
/
Sous-populations de lymphocytes B
/
Classification
/
Maladies de la jonction neuromusculaire
/
Transcriptome
/
Cytométrie en flux
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Experimental Neurobiology
Année:
2019
Type:
Article
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