Cerebral Amyloid Quantification in Cognitively Normal Korean Adults Using F-18 Florbetaben PET / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
;
: 334-339, 2019.
Article
Dans Anglais
| WPRIM
| ID: wpr-786490
ABSTRACT
PURPOSE:
To investigate regional cerebral amyloid beta retention in cognitively normal Korean adults using F-18 florbetaben (FBB).METHODS:
We prospectively analyzed F-18 FBB positron emission tomography (PET)/CT scans of 30 cognitively healthy adults (age range, 50??0 years) using automated quantification. The standardized uptake value ratios (SUVRs) of F-18 FBB were calculated for predefined regions by normalizing the regional count with cerebellar cortex.RESULTS:
The distribution of amyloid beta for each brain region revealed no age-related trends (p > 0.05). From all subjects, mean SUVR of amyloid deposit was 1.30 ± 0.18. The right parietal lobe showed the highest SUVR value (1.46 ± 0.23), whereas the right frontal lobe and left precuneus showed the lowest SUVR (1.23 ± 0.25).CONCLUSIONS:
We provide reference values of normative data obtained from healthy elderly Koreans and suggest its use for accurate diagnosis of patients with Alzheimer's disease.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Lobe pariétal
/
Valeurs de référence
/
Encéphale
/
Cortex cérébelleux
/
Études prospectives
/
Plaque amyloïde
/
Tomographie par émission de positons
/
Diagnostic
/
Maladie d'Alzheimer
/
Lobe frontal
Type d'étude:
Etude diagnostique
/
Étude observationnelle
Limites du sujet:
Adulte
/
Adulte très âgé
/
Humains
langue:
Anglais
Texte intégral:
Korean Journal of Nuclear Medicine
Année:
2019
Type:
Article
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