Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation Imaging in Neurological Diseases / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
;
: 283-296, 2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-786957
ABSTRACT
Neuroinflammation is heavily associated with various neurological diseases including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and stroke. It is strongly characterized by the activation of microglia which can be visualized using position emission tomography (PET). Traditionally, translocator protein 18 kDa (TSPO) has been the preferred target for imaging the inflammatory progression of the microglial component. TSPO is expressed in the outer mitochondrial membrane and present in very low concentrations in the healthy human brain, but is markedly upregulated in response to brain injury and inflammation. Due to its value as a marker of microglial activation and subsequent utility for evaluating neuroinflammation in CNS disorders, several classes of TSPO radioligands have been developed and evaluated. However, the application of these second-generation TSPO radiotracers has been subject to several limiting factors, including a polymorphism that affects TSPO binding. This review focuses on recent developments in TSPO imaging, as well as current limitations and suggestions for future directions from a medical imaging perspective.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Maladie de Parkinson
/
Encéphale
/
Lésions encéphaliques
/
Imagerie diagnostique
/
Microglie
/
Accident vasculaire cérébral
/
Membranes mitochondriales
/
Imagerie moléculaire
/
Maladie d'Alzheimer
/
Inflammation
Type d'étude:
Etude diagnostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Korean Journal of Nuclear Medicine
Année:
2017
Type:
Article
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