Beta-amyloid imaging in dementia / 영남의대학술지
Yeungnam University Journal of Medicine
;
: 1-6, 2018.
Article
Dans Anglais
| WPRIM
| ID: wpr-787101
ABSTRACT
Alzheimer's disease (AD) is a neurodegenerative disorder associated with extracellular plaques, composed of amyloid-beta (Aβ), in the brain. Although the precise mechanism underlying the neurotoxicity of Aβ has not been established, Aβ accumulation is the primary event in a cascade of events that lead to neurofibrillary degeneration and dementia. In particular, the Aβ burden, as assessed by neuroimaging, has proved to be an excellent predictive biomarker. Positron emission tomography, using ligands such as ¹¹C-labeled Pittsburgh Compound B or ¹⁸F-labeled tracers, such as ¹⁸F-florbetaben, ¹⁸F-florbetapir, and ¹⁸F-flutemetamol, which bind to Aβ deposits in the brain, has been a valuable technique for visualizing and quantifying the deposition of Aβ throughout the brain in living subjects. Aβ imaging has very high sensitivity for detecting AD pathology. In addition, it can predict the progression from mild cognitive impairment to AD, and contribute to the development of disease-specific therapies.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Encéphale
/
Maladies neurodégénératives
/
Démence
/
Tomographie par émission de positons
/
Maladie d'Alzheimer
/
Neuroimagerie
/
Dysfonctionnement cognitif
/
Ligands
langue:
Anglais
Texte intégral:
Yeungnam University Journal of Medicine
Année:
2018
Type:
Article
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