A Case of Long-term Survival with Autologous Recovery after Double Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 186-189, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-788546
ABSTRACT
A 1.1 year old boy was admitted to the Seoul National University Children's Hospital because of incidental findings of hepatosplenomegaly, skin lesion and multiple intra- abdominal lymphadenopathies. Anemia and thrombocytopenia were found based on the initial complete blood count (CBC) measurements. Because of bicytopenia and hepatosplenomegaly, bone marrow examination was performed which revealed hypercellular marrow with increased monocytes and granulopoiesis. The hemoglobin F level was high for his age, and monocyte production was increased. The patient was diagnosed with juvenile myelomonocytic leukemia at the age of 1.2 years. Chemotherapy with cytarabine, etoposide, vincristine, and isotretinoin was initiated. After 6 cycles of chemotherapy, the CBC normalized. He underwent double cord blood transplantation (dCBT), but chimerism studies showed autologous recovery. However, he did not show relapse during the 5 years post-transplant during which he received isotretinoin. He is surviving disease-free 9 years after dCBT.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Récidive
/
Peau
/
Thrombopénie
/
Vincristine
/
Hémogramme
/
Moelle osseuse
/
Myélogramme
/
Hémoglobine foetale
/
Monocytes
/
Isotrétinoïne
Type d'étude:
Etude diagnostique
Limites du sujet:
Humains
/
Mâle
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Clinical Pediatric Hematology-Oncology
Année:
2015
Type:
Article
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