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Antiepileptic Drugs in Children: Current Concept
Journal of Korean Neurosurgical Society ; : 296-301, 2019.
Article Dans Anglais | WPRIM | ID: wpr-788779
ABSTRACT
An epileptic seizure is defined as the transient occurrence of signs and/or symptoms due to abnormally excessive or synchronous neuronal activity in the brain. The type of seizure is defined by the mode of onset and termination, clinical manifestation, and by the abnormal enhanced synchrony. If seizures recur, that state is defined as epilepsy. Antiepileptic drugs (AEDs) are the mainstay of treatment. Knowledge about initiating and maintaining adequate AEDs is beneficial for the clinician who treats children with epilepsy. This article will delineate the general principles for selecting, introducing, and discontinuing AEDs and outline guidelines for monitoring adverse effects. In general, AED therapy following a first unprovoked seizure in children is not recommended. However, treatment should be considered after a second seizure. In children and adolescents, if they are seizure-free for at least 2 years, attempts to withdraw medication/s should be made, taking into account the risks vs. benefits for the individual patient. The decision on when and what AED to use should be tailored according to the patient. For optimal treatment, the selection of adequate AEDs can be achieved by considering the precise definition of the patient's seizure and epilepsy syndrome. Continuous monitoring of both therapeutic and adverse effects is critical for successful treatment with AEDs.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Crises épileptiques / Encéphale / Épilepsie / Anticonvulsivants / Neurones Type d'étude: Guide de pratique / Étude pronostique Limites du sujet: Adolescent / Enfant / Humains langue: Anglais Texte intégral: Journal of Korean Neurosurgical Society Année: 2019 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Crises épileptiques / Encéphale / Épilepsie / Anticonvulsivants / Neurones Type d'étude: Guide de pratique / Étude pronostique Limites du sujet: Adolescent / Enfant / Humains langue: Anglais Texte intégral: Journal of Korean Neurosurgical Society Année: 2019 Type: Article