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Roles and mechanisms of chemokine CX3CL1 in cerebral ischemia / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases ; (12): 706-710, 2019.
Article Dans Chinois | WPRIM | ID: wpr-789100
ABSTRACT
Chemokine CX3CL1 mainly participates in the physiological and pathological processes of nervous system by activating its receptor CX3CR1.Under physiological conditions,CX3CL1 can inhibit the activation of microglia;when cerebral ischemia and hypoxia,CX3CL1 can affect the expression of multiple downstream target genes involved in activation of adenosine receptor,inhibition of Ca 2+ influx,and promotion of blood vessel growth.It is of great significance to improve the energy metabolism disorder and to establish microcirculation around infarcts after cerebral ischemia.

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: International Journal of Cerebrovascular Diseases Année: 2019 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) langue: Chinois Texte intégral: International Journal of Cerebrovascular Diseases Année: 2019 Type: Article