Effect of combined treatment of small doses simvastatin and irbesartan on carotid intima-media thickness in patients with mild-to-moderate hypertension and normal serum lipid level / 上海预防医学
Shanghai Journal of Preventive Medicine
; (12): 222-225, 2015.
Article
de Zh
| WPRIM
| ID: wpr-789312
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WPRO
ABSTRACT
Objective] To observe the effect of combined treatment of small doses simvastatin and irbesartan for carotid intima-media thickness ( IMT ) in patients with mild-to-moderate hypertension and normal serum lipid level. [ Methods] A total of 124 patients with mild-to-moderate hypertension and normal serum lipid level were randomly divided into the observation group ( simvastatin combined with irbesartan) of 64 cases and the irbesartan group of 60 cases.Three months were as a course of treatment, and each patient in both groups received two courses;IMT,blood pressure and blood lipids were compared in the two groups before and after treatment. [ Results] After treatment of six months,systolic and diastolic blood pressure, IMT in both groups were significantly decreased, and IMT in the observation group was low-er than that in the control group ( all P<0.05) .In observation group, TC and LDL-C levels were signifi-cantly decreased, and HDL-C level was significantly increased (all P<0.01). [Conclusion] Besides lowering blood pressure and blood lipids levels, combined treatment of small doses simvastatin and irbesar-tan has good reverse effect on increased IMT and improves carotid atherosclerosis in patients with mild-to-moderate hypertension and normal serum lipid level.
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WPRIM
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Zh
Texte intégral:
Shanghai Journal of Preventive Medicine
Année:
2015
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Article