Variation analysis on serum uric acid level in hypertention with target organ damage / 上海预防医学

ABSTRACT

Objective To investigate the changes of the level of serum uric acid ( SUA ) in hypertension patients with target organ damage and its clinical significance. Methods From January 2013 to December 2014,a series of 1320 cases of primary hypertension in our hospital were included as a case group.According to the cases with or without target damage, they were allocated into two groupsorgan damaged and organ non-damaged,with 100 healthy cases as control group.The SUC levels deteced were compared between the groups. Results Of the 1320 cases with target organ damage, 1091 cases (82.65%) were found to have level of SUA significantly higher than that in control group (P<0.05);SUA level in organ damaged group was higher than that in non-damaged group ( P<0 .05 );SUA level in cases with 3 or more target organs damage was significantly higher than that in cases with 1 and 2 target organs damage(P<0.05),indicating a significant positive correlation.The age of hypertensive patients,and their SUA TC,TG,LDL-C,BUN,Cr,FBG,LVMI,SBP,DBP(r>0, P<0.05), were positively correlated with SUA, which was significantly negatively correlated with HDL-C (r<0, P<0.05).Multivariate logistic regression analysis showed that the hypertension course(OR=5.669), SBP(OR=4.323),DBP(OR=4.215),LVMI(OR=4.323),SCR(OR=4.215) and target organ damage(OR=7.145) all had remarkable impact with SUA levels in patients ( P <0.05 ) . Conclusion The level of SUA in hypertension is generally elevated and closely related with target organ damage and glucolipid metabolic disorder, and the course of hypertension.