Influence of endothelial progenitor cells mobilized by spironolactone on cardiac function in patients with myocardial infarction / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine
;
(6): 607-610, 2019.
Article
Dans Chinois
| WPRIM
| ID: wpr-790138
ABSTRACT
Objective:
To explore mobilizing effect of spironolactone by spironolactone on peripheral blood endothelial progenitor cells (EPCs) in patients with acute myocardial infarction ,and its impact on cardiac function .Methods:
A total of 136 patients with acute ST elevation myocardial infarction treated in our department were randomly and e‐qually divided into routine treatment group and spironolactone group (received spironolactone 20mg/time ,once/d based on routine treatment group ) ,both groups were treated for three months .Peripheral blood EPCs level before and 7d after treatment ,cardiac function indexes before and three months after treatment were compared between two groups.Results:
After 7d treatment ,peripheral blood EPCs level in spironolactone group was significantly high‐er than that of routine treatment group [ (1. 12 ± 0. 26)% vs.(0.53 ± 0. 14)%, P=0. 001].Compared with routine treatment group after three‐month treatment ,there was significant rise in LVEF [ (51. 47 ± 8.23)% vs.(56. 52 ± 8.84)%] ,and significant reductions in LVESd [(34. 52 ± 3. 16) mm vs.(32.90 ± 2. 68) mm] and LVEDd [(57. 82 ± 8.13) mm vs.(53. 65 ± 7.22) mm] in spironolactone group , P<0. 01 all.There was no significant difference in incidence rate of adverse reactions between two groups , P=0. 595.Conclusion:
Spironolactone can significantly in‐crease peripheral blood EPCs level and cardiac function ,and inhibit myocardial remodeling in AMI patients .
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
langue:
Chinois
Texte intégral:
Chinese Journal of cardiovascular Rehabilitation Medicine
Année:
2019
Type:
Article
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