Decreasing effect of semen Trichosanthis oil on blood glucose on diabetic mice / 药学实践杂志

ABSTRACT

Objective To study the hypoglycemic activity of semen Trichosanthis oil(STO) and the mechanism on dia-betic mice .Methods The alloxan-induced diabetic mice were divided into different groups and given different dose of STO by gavage for 4 weeks ,the changes of body weight and fasting blood glucose were investigated every week .Blood serum was drawn to determine TC ,TG ,NO ,NOS and insulin .In addition ,the effect of STO on glucose tolerance were also investigated in alloxan-induced diabetic mice .Results STO can dose dependently reduce the levels of blood glucose and increase the body weight when it was administrated orally at 5 ,10 ,20 ml?kg -1 ,can increase insulin and lower TC ,TG ,NO ,NOS in blood ser-um ,and also can improve glucose tolerance in alloxan-induced diabetic mice .Conclusion STO may potentiate the hypoglycemic effect ,and can improve glucose tolerance .The hypoglycemic activity of STO may be related with increasing insulin and decrea-sing NO and NOS in blood serum .