Epidemiological characteristics of non-fermentative bacteria causing bloodstream infection in Sichuan:a retrospective multicenter study / 中华微生物学和免疫学杂志

ABSTRACT

Objective To retrospectively analyze the distribution of non-fermentative bacteria cau-sing bloodstream infection in hospitalized patients in Sichuan Province and their drug susceptibility to com-mon antibiotics for better understanding their epidemiological characteristics. Methods From January 1, 2015 to December 31, 2017, all of the non-fermentative bacteria isolated from patients with bloodstream in-fection in nine hospitals in Sichuan Province were collected. Species distribution and drug resistance test re-sults were retrospectively analyzed. Results A total of 6291 strains of pathogenic bacteria were isolated, including 3674 strains of gram-negative bacteria ( 58. 4％) and 2617 strains of gram-positive bacteria (41. 6％). The gram-positive bacteria were 1895 strains of Staphylococcus (30. 1％), 372 strains of Strep-tococcus (5. 9％), 317 strains of Enterococcus (5. 1％) and 33 strains of other gram-positive bacteria (0. 5％). The gram-negative bacteria were 3191 Enterobacteriaceae strains (50. 7％), 389 non-fermenta-tive strains (6. 2％) and 94 other gram-negative strains (1. 5％). The isolated non-fermentative bacteria were mainly Pseudomonas aeruginosa ( 136 strains, 35. 0％), Acinetobacter baumannii ( 126 strains, 32. 0％) and Stenotrophomonas maltophilia ( 33 strains, 8. 5％). There were 167 ( 42. 9％), 112 (28. 8％) and 82 (21. 1％) non-fermentative bacteria isolated in internal medicine departments, ICUs and surgery departments, respectively. The drug resistance rates of Pseudomonas aeruginosa to cefepime, cipro-floxacin and gentamicin were 16. 5％, 10. 7％ and 9. 9％, respectively. Carbapenems-resistant Pseudo-monas aeruginosa ( CR-PA) accounted for 13. 6％. No polymyxin-resistant Pseudomonas aeruginosa was found. The resistance rates of Acinetobacter baumannii to all antibiotics were over 30％ except for minocy-cline and polymyxin and 75. 7％ of carbapenem-resistant Acinetobacter baumannii ( CR-AB) were isolated. The drug resistance rates to levofloxacin, trimethoprim/sulfamethoxazole and ceftazidime were 0％, 0％ and 37. 0％ in Stenotrophomonas maltophilia isolates and 10. 5％, 4. 2％ and 19％ in Burkholderia cepacia iso-lates, respectively. Conclusions Non-fermentative bacteria causing 6. 2％ of bloodstream infection in Si-chuan, mainly by Pseudomonas aeruginosa and Acinetobacter baumannii. There were significant differences in the isolation rate of non-fermentative bacteria in different departments and most of the strains were isolated in internal medicine departments. The detection rate of Acinetobacter baumannii with multiple drug resistance was high, while other non-fermentative bacteria had good sensitivity to antibiotics.