A study on the relationship between smoking and blood inflammatory cytokines as well as atherosclerosis / 预防医学

ABSTRACT

Objective To explore the influence of long -term smoking on the level of blood inflammatory cytokines and the degree of atherosclerosis in healthy middle -aged men.Methods A total of 84 middle -aged men who accepted the health examination were divided into smoking group and non -smoking group.The risk factors of atherosclerosis,such as age,body mass index (BMI),systolic blood pressure (SBP),diastolic blood pressure (DBP),fasting blood glucose (GLU),total cholesterol (TC),low density lipoprotein (LDL),high density lipoprotein (HDL)and triglyceride (TG) were recorded.The white blood cell (WBC)level and neutrophil cell (NC)level were also recorded.The interleukin -6 (IL -6)concentration was assayed by using enzyme -linked immunosorbent double antibody method and the high -sensitivity C reactive protein (Hs -CRP)concentration was assayed by using immune turbidimetry method.The carotid artery intima -media thickness (IMT)and plaques were measured by B -mode ultrasonography.Results There were no significant differences in the risk factors of atherosclerosis between the two groups.But there were statistically significant differences between smoking group and non -smoking group in IL -6 (1 .46 ±0.27 vs.1 .21 ±0.24),Hs -CRP (6.57 ±2.47 vs.3.1 4 ±2.07),WBC (5.78 ±0.79 vs.5.25 ±0.64)and NC (3.40 ±0.45 vs.2.87 ±0.42)(P <0.05). The carotid artery IMT in smoking group was significantly thicker than that of the non -smoking group (1 .0 ±0.1 8 vs. 0.82 ±0.1 6,P <0.01 ).The detection rate of plaque and carotid stenosis in smoking group was significantly higher than that of the non -smoking group (P <0.01 ).Conclusion Long -term smoking not only leads to increased inflammatory cytokines,but also aggravates the degree of atherosclerosis in healthy middle -aged men.Long -term smoking healthy middle -aged men are potential in patients with cardiovascular disease.