Expression of TRAIL (Apo-2L)/TRAIL Receptor System Related to Apoptosis at the Human Extraembryonic Tissues and Gestational Trophoblastic Disease / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
; : 2156-2161, 2003.
Article
de Ko
| WPRIM
| ID: wpr-79243
Bibliothèque responsable:
WPRO
ABSTRACT
Human uterus has been known as a immune privileged site for the product of conception. At the feto-maternal interface, Fas system is a underlying main mechanism of maternal immune acceptance. To date, the TRAIL (TNF-related apoptosis-inducing ligand) system is known to be another pivotal mechanism. OBJECTIVE: To clarify the protein expression of TRAIL ligand and receptors in the normal and pathologic (preeclampsia, hydatidiform mole) placenta, chorioamnion, decidua. METHODS: we investigated the expression of TRAIL system in the above-mentioned tissues by using Western Hybridization. RESULTS: All tissues expressed TRAIL ligand and only a DcR2 among TRAIL receptors (DR4, DR5, DcR1, DcR2). CONCLUSION: we demonstrated the expression of TRAIL ligand and DcR2 protein at the feto-maternal interface of the normal and pathologic pregnancies. Further study regarding the expression of other receptors and quantitative analysis between normal and pathologic pregnancies should be followed.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Placenta
/
Utérus
/
Apoptose
/
Caduques
/
Maladie trophoblastique gestationnelle
/
Récepteurs de TRAIL
/
Fécondation
Limites du sujet:
Female
/
Humans
/
Pregnancy
langue:
Ko
Texte intégral:
Korean Journal of Obstetrics and Gynecology
Année:
2003
Type:
Article