Research advances of interleukin-17 in pathogenesis of non-alcoholic fatty liver diseases / 中华实用儿科临床杂志
Chinese Journal of Applied Clinical Pediatrics
;
(24): 1508-1511, 2019.
Article
Dans Chinois
| WPRIM
| ID: wpr-803022
ABSTRACT
In recent years, with the development of economy, the improvement of people′s living standards, the change of lifestyle and the prevalence of obesity and diabetes, the incidence rate of non-alcoholic fatty liver disease(NAFLD) in the world is increasing year by year.NAFLD is a sort of liver disease spectrum associated with genetics-environment-metabolic stress and is a common multifactorial involvement of liver disease.Interleukin(IL)-17 is a pro-inflammatory factor mainly produced by T helper cell 17.Recently, it has been found that the expression of IL-17 is increased in various liver diseases, and relevant studies have confirmed that IL-17 can facilitate the occurrence and development of NAFLD, and the underlying mechanisms are related to insulin resistance, oxidative stress, lipid peroxidation, gut microbiota dysbiosis, immune inflammation and lipoapoptosis, etc.Now, the research advances of IL-17 in the pathogenesis of NAFLD are reviewed.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Type d'étude:
Etude d'étiologie
langue:
Chinois
Texte intégral:
Chinese Journal of Applied Clinical Pediatrics
Année:
2019
Type:
Article
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