Increasing and Worsening Late Effects in Childhood Cancer Survivors during Follow-up
Journal of Korean Medical Science
; : 755-762, 2013.
Article
Dans En
| WPRIM
| ID: wpr-80571
Responsable en Bibliothèque :
WPRO
ABSTRACT
Recent advances in childhood cancer treatment have increased survival rates to 80%. Two out of three survivors experience late effects (LEs). From a group of 241 survivors previously described, 193 were followed at the long-term follow-up clinic (LTFC) of Severance Hospital in Korea; the presence of LEs was confirmed by oncologists. We reported the change in LEs during 3 yr of follow-up. The median follow-up from diagnosis was 10.4 yr (5.1-26.2 yr). Among 193 survivors, the percentage of patients with at least one LE increased from 63.2% at the initial visit to 75.1% at the most recent visit (P = 0.011). The proportion of patients having multiple LEs and grade 2 or higher LEs increased from the initial visit (P = 0.001 respectively). Forty-eight non-responders to the LTFC were older and had less frequent and severe LEs than responders at initial visit (all P < 0.05). In multivariate analysis, younger age at diagnosis, older age at initial visit, a diagnosis of a brain tumor or lymphoma, and use of radiotherapy were significant risk factors for LEs (all P < 0.05). Adverse changes in LEs were seen among the survivors, regardless of most clinical risk factors. They need to receive comprehensive, long-term follow up.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Indice de gravité de la maladie
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Tumeurs du cerveau
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Cellules souches hématopoïétiques
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Analyse multifactorielle
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Taux de survie
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Facteurs de risque
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Études de suivi
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Facteurs âges
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Transplantation de cellules souches hématopoïétiques
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Évolution de la maladie
Type d'étude:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limites du sujet:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
langue:
En
Texte intégral:
Journal of Korean Medical Science
Année:
2013
Type:
Article